El-Escorial diagnostic criteria for ALS
Upper and lower motor neuron signs in three regions.
Upper and lower motor neuron signs in at least two regions, with upper motor neuron signs rostral to lower motor neuron signs.
Upper and lower motor neuron signs in one region, upper motor neuron signs alone in two or more regions, or lower motor neuron signs rostral to upper motor neuron signs.
Lower motor neuron signs only, in two or more regions.
References
Clinical diagnosis and management of amyotrophic lateral sclerosis. Nat Rev Neurol. 2011 Oct 11;7(11):639-49
doi:
10.1038/nrneurol.2011.153
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