Airlie House diagnostic criteria for ALS
Clinical or electrophysiological evidence demonstrated by the presence of upper and lower motor neuron signs in the bulbar region and at least two spinal regions, or the presence of upper and lower motor neuron signs in three spinal regions.
Clinical or electrophysiological evidence demonstrated by upper and lower motor neuron signs in at least two spinal regions, with some upper motor neuron signs necessarily rostral to the lower motor neuron signs.
Clinical or electrophysiological signs of upper and lower motor neuron dysfunction in only one region, or upper motor neuron signs alone in two or more regions, or lower motor neuron signs rostral to upper motor neuron signs.
References
Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials Neurology 2019 Apr 2;92(14):e1610-e1623
doi:
10.1212/WNL.0000000000007242
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