IgG4-RD diagnostic criteria
1. Clinical and radiological features
One or more organs show diffuse or localized swelling or a mass or nodule characteristic of IgG4-RD. In single organ involvement, lymph node swelling is omitted
2. Serological features
Serum IgG4 levels >135 mg/dl
3. Histopathological features
Dense lymphocyte and plasma cell infiltration with fibrosis
Ratio of IgG4+ plasma cells/IgG+ cells >40% and the number of IgG4+ plasma cells >10 per high powered field
Typical tissue fibrosis, particularly storiform fibrosis, or obliterative phlebitis
References
The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD Mod Rheumatol. 2021 May;31(3):529-533
doi:
10.1080/14397595.2020.1859710
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