Prasugrel

Trade names

EFFIENT

Actions

• P2Y12 receptor antagonist.

Route of Administration

Oral

Bioavailability

80%

Plasma protein binding

98%

Time to peak plasma concentration

30 min

Time to plasma steady state

0.5-4 h

Half-life

7 h

Elimination

Renal ~68%

Biliary: ~27%

Duration of action

7–10 days

Reversible platelet inhibition

No

Recommended dose

Loading dose: 60 mg

Maintenance dose: 10 mg once daily

Renal impairment

Should be used with caution in patients with moderate to severe renal impairment.

Discontinuation before invasive procedures

10 days