Low Molecular Weight Heparins

Trade names

FRAGMIN (Dalteparin)

FRAXIPARIN, FRAXODI (Nadroparin)

INNOHEP (Tinzaparin)

LOVENOX (Enoxaparin)

SANDOPARIN, EMBOLEX (Certoparin)

Actions

• Direct factor Xa inhibitors
• Direct thrombin inhibitors

Route of Administration

Subcutaneous

Bioavailability

90%

Plasma protein binding

<90%

Time to peak plasma concentration

3 h

Half-life

4 h

Duration of action

Dose dependent

Metabolism

Hepatic and reticulo-endothelial system.

Elimination

Renal 10-70%

Recommended dose

Variable by specific drug.

Renal impairment

Cautious use and dose reduction might be necessary in patients with renal impairment.

Discontinuation before invasive procedures

Usually discontinued 12-24 hours before surgery.