Clopidogrel

Trade names

PLAVIX

Actions

• P2Y12 receptor antagonist.

Route of Administration

Oral

Bioavailability

50%

Plasma protein binding

94–98%

Time to peak plasma concentration

1 h

Time to plasma steady state

2–8 h

Half-life

7–8 hours

Elimination

Renal 50% Biliary 46%

Duration of action

7–10 days

Reversible platelet inhibition

No

Recommended dose

75 mg once daily

Renal impairment

Should be used with caution in patients with moderate to severe renal impairment.

Discontinuation before invasive procedures

7 days