Acetylsalicylic acid

Trade names

ASPIRIN

Actions

• Irreversibly inhibits COX1 and, in higher doses, COX2.

Route of Administration

Oral

Bioavailability

80–100%

Plasma protein binding

80–90%

Time to peak plasma concentration

30–40 min

Time to plasma steady state

The serum half-life of salicylic acid is dose-dependent. The larger the dose administered the longer it will take to reach steady-state.

Half-life

15–30 min

Metabolism

Hepatic

Elimination

Renal

Duration of action

7–10 days

Reversible platelet inhibition

No

Recommended dose

75–100 mg once daily

Renal impairment

Contraindicated in severe renal impairment (creatinine clearance <30 ml/min).

Discontinuation before invasive procedures

0–5 days