Pramipexole

Trade names

  • MIRAPEX
  • MIRAPEXIN
  • SIFROL

Actions

  • Agonist of D2S, D2L D3 and D4 dopamine receptors

Route of Administration

Oral

Bioavailability

>90%

Plasma protein binding

15%

Half-life

8–12 hours

Metabolism

Not significantly metabolized

Elimination

Renal 90%, biliary 2%

Important side-effects

Excessive sleepiness.

Impaired impulse control (gambling, compulsive shopping, compulsive eating, etc).

Hypersexuality.

Confusion, hallucinations, delusions, psychosis.

Dyskinesia.

Orthostatic hypotension.

Recommended dose

Start with 0.375 mg once daily.

Increase every 5 to 7 days, first to 0.75 mg / day and then by increments of 0.75 mg / day until the optimal dose is reached.

The maximum dose of pramipexole is 4.5 mg / day.

Renal impairment

Creatinine clearance (ml/min/1.73 m2)Dose and frequency
>50No dose reduction
20-50Max dose 2.25 mg / day.
<20Max dose 1.5 mg / day.

Hepatic impairment

No dose reduction is necessary.