Pramipexole
Trade names
- MIRAPEX
- MIRAPEXIN
- SIFROL
Actions
- Agonist of D2S, D2L D3 and D4 dopamine receptors
Route of Administration
Oral
Bioavailability
>
90%
Plasma protein binding
15%
Half-life
8–12 hours
Metabolism
Not significantly metabolized
Elimination
Renal 90%, biliary 2%
Important side-effects
Excessive sleepiness.
Impaired impulse control (gambling, compulsive shopping, compulsive eating, etc).
Hypersexuality.
Confusion, hallucinations, delusions, psychosis.
Dyskinesia.
Orthostatic hypotension.
Recommended dose
Start with 0.375 mg once daily.
Increase every 5 to 7 days, first to 0.75 mg / day and then by increments of 0.75 mg / day until the optimal dose is reached.
The maximum dose of pramipexole is 4.5 mg / day.
Renal impairment
Creatinine clearance (ml/min/1.73 m2) | Dose and frequency |
---|---|
>50 | No dose reduction |
20-50 | Max dose 2.25 mg / day. |
< 20 | Max dose 1.5 mg / day. |
Hepatic impairment
No dose reduction is necessary.