Benztropine

Trade names

• COGENTIN

Actions

• Selective M1 muscarinic acetylcholine receptor antagonist.

Route of Administration

Oral (IM and IV formulations also exist)

Bioavailability

29%

Half-life

12-24 hours

Metabolism

Hepatic

Elimination

Renal

Important side-effects

Memory problems, confusion, delirium, psychosis.

Dry mouth, constipation, ileus, urinary retention.

Tachycardia.

Should not be given to patients with untreated closed angle glaucoma.

Recommended dose

Start with a single daily dose of 0.5-1 mg at bedtime.

Titrate after effect and tolerance. Some patients may require up to 4-6 mg per day.

Renal impairment

Use with caution in patients with renal impairment.

Hepatic impairment

Use with caution in patients with hepatic impairment.