Injectable AEDs

1. Fosphenytoin

Status epilepticus:

15-20 mg PE/kg IV (PE = phenytoin equivalent)

Non-emergent administration:

10-20 mg PE/kg IV or IM. Infusion rate should not exceed 150 mg PE/minute.

2. Valproate

Status epilepticus:

25mg/kg IV. Infusion rate should not exceed 300mg/min. Reduce dose to 10mg/kg if the patient is already treated with valproate.

Non-emergent administration:

No loading dose. Administer 1000-2500 mg/day in 1-3 divided doses.

3. Levetiracetam

Status epilepticus:

1000-4500 mg IV

Non-emergent administration:

No loading dose. Administer 1000 mg/day divided in 2 doses.

Dose can be increased by 1000 mg/day every 2 weeks up to a maximum total dose of 3000 mg/day.

4. Lacosamide

Non-emergent administration:

No loading dose. Maintenance dose 200-400 mg/day IV divided in 2 doses. Infused over 30-60 min.