Anterior horn cell syndrome

Causes

• Spinal muscular atrophies (SMA types I-IV)
• Kennedy syndrome
• Hirayama disease
• Tangier disease
• Hexosaminidase deficiency
• Poliomyelitis and post-polio syndrome
• Flail arm/leg variants of motor neuron disease
• Postradiation syndrome

Clinical presentation

• Flaccid weakness with LMN motor signs, reduced muscle tone, fasciculations and atrophy in affected segments